phenmorphic acid

cas: 2613-89-0molecular formula: c9h8o4molecular weight: 180.16chinese name:

phenylmorphic acid

phenylmalonic acid

english name:

phenyl-propanedioic acid

phenylmalonic acid

description of properties: prismatic crystal. melting point 153-155°c (decomposition). soluble in water, ethanol, ether, slightly soluble in chloroform, carbon disulfide, benzene. production method: obtained by hydrolysis of diethyl phenylmalonate. hydrolysis: first add absolute ethanol into the reaction pot, stir and add granulated alkali until it is completely dissolved, cool to 45-50°c, add diethyl phenylmalonate dropwise, finish adding in about 2-3 hours, keep warm for 2 hours, and then cool to 10-15°c, filter, dry at 60°c, and pulverize to obtain sodium phenylmalonate with a yield of 90%. acidification: put acetone in the reaction pot, add sodium phenylmalonate, cool to 10°c, add sulfuric acid dropwise to ph=1.0-0.5. filter, wash the filter cake four times with acetone and discard it, combine the filtrate and the washing liquid, concentrate and recover the acetone with a thin film evaporator until thick, add toluene to crystallize at 15°c and filter, wash the filter cake with toluene, filter dry, and dry , to obtain phenylmalonic acid with a yield of 76%. usage: this product is an intermediate of the antibiotic drug carbenicillin sodium.