structural formula
| business number | 03rp |
|---|---|
| molecular formula | c14h22n2o |
| molecular weight | 234.34 |
| label |
n-diethylaminoacetyl-2,6-dimethylaniline, xylocaine, xylocaine, lidocaine base, n-diethylacetyl-2,6-dimethylaniline, 2-diethylamino-n-(2,6-dimethylphenyl)acetamide, 2-diethylamino-n-(2,6-dimethylphenyl)acetamide, lignocaine, xylocaine, aromatic compounds |
numbering system
cas number:137-58-6
mdl number:mfcd00026733
einecs number:205-302-8
rtecs number:an7525000
brn number:none
pubchem number:24896480
physical property data
1. appearance: white crystalline powder
2. melting point (℃): 76~79
3. solubility: easily soluble in water or ethanol, soluble in chloroform , insoluble in ether.
toxicological data
none
ecological data
none
molecular structure data
1. molar refractive index: 72.42
2. molar volume (cm3/mol): 228.3
3. isotonic specific volume (90.2k): 571.1
4. surface tension (3.0 dyne/cm): 39.1
5. polarizability (0.5 10-24cm3): 28.71
compute chemical data
1. reference value for hydrophobic parameter calculation (xlogp): none
2. number of hydrogen bond donors: 1
3. number of hydrogen bond acceptors: 2
4. number of rotatable chemical bonds: 5
5. number of tautomers: 3
6. topological molecule polar surface area 32.3
7. number of heavy atoms: 17
8. surface charge: 0
9. complexity: 228
10. number of isotope atoms: 0
11. determine the number of atomic stereocenters: 0
12. uncertain number of atomic stereocenters: 0
13. determine the number of chemical bond stereocenters: 0
14. number of uncertain chemical bond stereocenters: 0
15. number of covalent bond units: 1
properties and stability
none
storage method
this product should be sealed and stored in a cool, dry place.
synthesis method
1. chloroacetyl chloride method
2,6-dimethylaniline undergoes chloroacetylation with chloroacetyl chloride, then condenses with diethylamine, and then acidifies to form a salt to obtain lidocaine.
2. diethylaminoacetic acid methyl ester method
in the presence of sodium methoxide, 2,6-dimethylaniline and n,n-diethylaminoacetic acid methyl ester are condensed, it is then acidified to form a salt to obtain the product.
purpose
widely used for topical anesthesia, infiltration anesthesia, conduction anesthesia, and epidural anesthesia. it is also an important drug in the treatment of sudden arrhythmias.
