Synthetic route of 4-chloro-3-nitrobenzene_Kain Industrial Additive

overview[1][2] 4-chloro-3-nitrobenzene is the main raw material for the synthesis of rheumatoid arthritis treatment drug iguratimod (t-164). there is no industrial production in china and it mainly relies on imports. its traditional synthesis method it is mainly produced from p-nitroanisole as raw material through a five-step reaction of reduction, acetylation, nitration, hydrolysis, and diazochlorination. however,…