Preparation of Sitagliptin Impurity 13_Kain Industrial Additive

background and overview[1] sitagliptin, chemical name (2r)-4-oxo-4-[3-trifluoromethyl-5,6-dihydro[1,2,4]triazole[4 , 3-a]pyrazin-7(8h)-yl]-1-(2,4,5-trifluorophenyl)-butan-2-amine, which is a dipeptide developed by merck, usa the first product of dpp-vi (dpp-vi) inhibitor. in october 2006, its phosphate monohydrate was approved by the us fda as the first dipeptidyl peptidase-vi (dpp-vi) inhibitor for clinical use in the treatment of type 2 diabetes. the advantage…