Preparation of N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodoquinazolin-4-amine_Kain Industrial Additive

[overview] n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodoquinazolin-4-amine is an important intermediate in the synthesis of lapatinib. [preparation method] 1. use 2-aminobenzonitrile as raw material, iodide to obtain 2-amino-5-iodobenzonitrile, and then condense it with n,n-dimethylformamide dimethyl acetal (dmf?dma) n’-(2-cyano-4-iodophenyl)-n,n-dimethylformamidine. excess dmf?dma was evaporated under reduced pressure, and glacial acetic acid and 3-chloro-4-[(3-fluorobenzyl)oxy]aniline were added to perform dimroth rearrangement to obtain n-{3-chloro-4-[(3-…