Preparation of methyl 3-methyl-4-nitrobenzoate_Kain Industrial Additive

background and overview[1][2] methyl 3-methyl-4-nitrobenzoate is a pharmaceutical intermediate that can be obtained by one-step esterification of 3-methyl-4-nitrobenzoic acid. it is the starting material for preparing the antihypertensive drug telmisartan. preparation[1-2] report 1, add 300g 3-methyl-4-nitrobenzoic acid (1.66mol) and 1000ml methanol into a dry 3l three-necked flask equipped with a reflux condenser and a thermometer,…