Preparation of ethoxyformylethyltriphenylphosphine bromide_Kain Industrial Additive

background and overview[1] ethoxyformylethyl triphenylphosphine bromide is an organic intermediate that can be prepared in one step from triphenylphosphine and ethyl 2-bromopropionate. ethoxyformylethyltriphenylphosphine bromide can be used to prepare 2-c-methyl-4,5-o-(1-methylvinyl)-d-arabinonate ethyl ester, 2-c-methyl ethyl-4,5-o-(1-methylvinyl)-d-arabinonate is a key intermediate in the synthesis of sofosbuvir. preparation[1] add 28.8g (0.11mol) triphenylphosphine and 18.1g (0.1mol) ethyl 2-bromopropionate into 157ml…