Preparation of 3′-fluoroacetophenone_Kain Industrial Additive

background and overview 3′-fluoroacetophenone, also known as m-fluoroacetophenone, is a commonly used drug synthesis intermediate, preparation[1-2] method 1, catalyst [(ipr)aucl] (3.1mg, 0.5mol%), 3-fluorophenylacetylene (1mmol), methanol (1ml) and water (0.5ml) were added to the 25ml reactor in sequence. the reaction mixture was reacted at 110°c for 6 hours and then cooled to room temperature. the solvent…