Preparation of 3-bromo-5-nitrobenzamide_Kain Industrial Additive

background and overview[1][2] 3-bromo-5-nitrobenzamide is a poly(adp-ribose) polymerase inhibitor. as an anti-tumor agent, it is currently in the clinical research stage and has good clinical prospects. 3-bromo-5-nitrobenzamide preparation[2] method 1: step 1: preparation of 3-nitrile-5-nitroaniline. into a 500ml three-necked flask, add 21.6g (0.1mol) 3-bromo-5-nitroaniline, 10g (0.12mol) cuprous cyanide, 200ml dmf, stir, and heat to react…