preparation of (2r,3s)-3-benzamido-2-hydroxy-3-phenylpropionic acid methyl ester_kain industrial additives
background and overview[1] (2r,3s)-3-benzoylamino-2-hydroxy-3-phenylpropionic acid methyl ester can be passed through 3-hydroxy-4-phenylazetidin-2-one (hpa) it is prepared in two steps and can be used to prepare paclitaxel. paclitaxel is a mitotic inhibitor or spindle poison and is a new type of anti-microtubule drug. preparation[1] step a, preparation of 3-phenylisoserine methyl ester hydrochloride dissolve 50g of 3-hydroxy-4-phenylazetidin-2-one…
preparation of (2r, 3s)-3-(benzoylamino)-2-hydroxyphenylpropionic acid ethyl ester_kain industrial additive
background and overview[1] (2r, 3s)-3-(benzoylamino)-2-hydroxyphenylpropanoic acid ethyl ester is an important synthetic intermediate that can be used to synthesize the anti-cancer drug paclitaxel. the traditional synthesis method of (2r, 3s)-3-(benzoylamino)-2-hydroxyphenylpropionate ethyl ester mainly involves asymmetric dihydroxylation of α and β unsaturated esters, followed by azide substitution and reduction. be made of. preparation[1] 1) add 0.786g…
preparation of (2r,4s)-5-(biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid_kain industrial additive
background and overview[1] (2r,4s)-5-(biphenyl-4-yl)-4-[(tert-butoxycarbonyl) amino]-2-methylpentanoic acid is a key intermediate in the preparation of sacubitril. sacubitril and valsartan can form the compound drug entresto at a ratio of 1:1. entresto is a first-in-class medicine developed by novartis to reduce the risk of cardiovascular death and hospitalization for heart failure and to reduce ejection fraction in…
