Preparation of 2-trifluoromethylbenzonitrile_Kain Industrial Additive

background and overview[1] 2-trifluoromethylbenzonitrile can be used as a pharmaceutical synthesis intermediate and can be prepared by reacting 2-trifluoromethylbenzaldehyde as raw material and hydroxylamine hydrochloride. preparation[1-2] report 1, combine 2-trifluoromethylbenzaldehyde (2.0mmol, 1.0 equivalent), h2noh·hcl (153mg, 2.2mmol), na2co3 (117 mg, 1.1 mmol) and dmso (10 ml, 0.2 m) were added to an oven-dried reaction tube (30…