Preparation of 2-ethoxybenzamidine hydrochloride_Kain Industrial Additive

background and overview[1] 2-ethoxybenzamidine hydrochloride is a pharmaceutical intermediate that can be prepared from 2-ethoxybenzonitrile in one step. there are reports in the literature that 2-ethoxybenzamidine hydrochloride can be used to prepare phosphodiesterase inhibitors. preparation[1] suspend 21.4 g (400 mmol) ammonium chloride in 375 ml toluene and cool the suspension to 0°c. 200 ml of…