Preparation of 2-(difluoromethyl)benzaldehyde_Kain Industrial Additive

background and overview[1] 2-(difluoromethyl)benzaldehyde is an organic intermediate. there are reports in the literature that 2-(difluoromethyl)benzaldehyde can be prepared in one step from 1-bromo-2-difluoromethylbenzene and dmf. . preparation[1-2] report 1, after dissolving 1-bromo-2-difluoromethylbenzene (3.23g) in tetrahydrofuran (65ml), the mixture was cooled to -78°c. n-butyllithium (2.64m solution in hexane, 6.5ml) was then added and stirred for…