Preparation of (2-butyl-5-nitro-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone_Kain Industrial Additive

background and overview[1] synthesis of (2-butyl-5-nitro-3-benzofuryl)[4-[3-(dibutylamino)propoxy]phenyl]methanone as dronedarone hydrochloride intermediate. dronedarone hydrochloride, chemical name: n-(2-butyl-3-(4-(3-dibutylaminopropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide hydrochloride salt is an antiarrhythmic drug. preparation[1] the preparation of (2-butyl-5-nitro-3-benzofuryl)[4-[3-(dibutylamino)propoxy]phenyl]methanone is as follows: the specific steps are as follows: at room temperature, put in butanone (240l), potassium carbonate (17.9kg), 2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran (40.0kg) ) and n-(3-chloropropyl)dibutylamine (26.6kg) into the reaction kettle,…