Preparation of 2-bromo-1-chloro-4-trifluoromethoxybenzene_Kain Industrial Additive

background and overview[1-2] 2-bromo-1-chloro-4-trifluoromethoxybenzene is a pharmaceutical intermediate, which can be prepared from 2-bromo-4-(trifluoromethoxy)aniline after diazotization and chlorination. 2-bromo-1-chloro-4-trifluoromethoxybenzene can be used to prepare triazolecarboxylic acid derivatives (such as 4-((4′-chloro-3′-(trifluoromethoxy)-[1, 1,-biphenyl]-4-yl)thio)-1h-1,1,2,3-triazole-5-carboxylic acid), these derivatives can be used as glycolate oxidase inhibitors. preparation[1-2] report 1, a solution of sodium nitrite (0.81g, 11.72mmol) in water (2ml) was…