Preparation of 1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene_Kain Industrial Additive

background and overview[1] 1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene is a key intermediate in the preparation of dapagliflozin. dapagliflozin is a sodium-glucose cotransporter 2 (sglt2) inhibitor used to treat type 2 diabetes. it is a c-aryl glucoside compound with the chemical name: (2s, 3r, 4r, 5s, 6r)- 2-[3-(4-ethoxybenzyl)-4-chlorophenyl]-6-hydroxymethyltetrahydro-2h-pyran-3,4,5-triol. dapagliflozin inhibits the reabsorption of blood sugar by inhibiting renal sodium-glucose cotransporter…