Preparation of 1-(4-hydroxyphenyl)piperazine dicyanobromide_Kain Industrial Additive

overview[1] 1-(4-hydroxyphenyl)piperazine dicyanobromide can be used as a pharmaceutical synthesis intermediate, such as the preparation of 1-acetyl-4-(4-hydroxyphenyl)piperazine, ketoconazole (ketoconazole) ) is a highly effective, low-toxic, orally effective broad-spectrum antifungal drug. one of its key intermediates is 1-acetyl-4-(4-hydroxyphenyl)piperazine. preparation[1] 1-(4-hydroxyphenyl)piperazine dicyanobromide is prepared as follows: 1) synthesis of dibromoethylamine hydrobromide add 194ml of diethanolamine (210g, 2.0mol)…