Preparation method of (R)-2-(9-(pyridin-2-yl)-6-dioxaspiro[4.5]decan-9-yl)acetonitrile_Kain Industrial Additive

background and overview[1] (r)-2-(9-(pyridin-2-yl)-6-dioxaspiro[4.5]decan-9-yl)acetonitrile is a pharmaceutical intermediate that can be synthesized from but-3-ene -l-alcohol and cyclopentanone are used as starting materials and are prepared through a six-step reaction. preparation[1] preparation of 1,6-oxaspiro[4.5]dec-9-ol (c) to a solution of but-3-en-l-ol (100 g, 1.38 mol) was added cyclopentanone (232 g, 2.77 mol) in dichloromethane (dcm) (1,200 ml).…