Preparation method of 7-bromobenzofuran-2-carboxylic acid_Kain Industrial Additive

background and overview[1] 7-bromobenzofuran-2-carboxylic acid can be used as a pharmaceutical synthesis intermediate. preparation[1] method 1: the preparation of 7-bromobenzofuran-2-carboxylic acid is divided into the following two steps: 1) 3-bromo-2-hydroxybenzaldehyde. add 20.0g (115.6mmol) of 2-bromophenol to 500ml of anhydrous acetonitrile. add 16.84g (176.87mmol) anhydrous magnesium chloride, 23.4g paraformaldehyde particles and 41.9ml (300.6mmol) triethylamine. the reaction…