Preparation method of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride_Kain Industrial Additive

background and overview[1] 4-(4-methyl-1-piperazinylmethyl)benzoic acid dihydrochloride is a key intermediate for the preparation of imatinib mesylate. imatinib mesilate, chemical name is 4-(4-methylpiperazinyl-1-methyl)-n-[4-methyl-3-[4-(3-pyridyl) pyrimidine-2-amino]-benzamide methanesulfonate. imatinib mesylate is a small molecule tyrosine kinase (tk) inhibitor. its mechanism of action is to target the bcr/abl receptor subtype of tyrosine kinase and selectively bind to bcr/abl protein tyrosine…