Preparation method of 2-nitro-p-phenylenediamine_Kain Industrial Additive

background and overview[1-4] 2-nitro-1,4-phenylenediamine, also known as 2-nitro-1,4-phenylenediamine, is an important pharmaceutical raw material that can be used to synthesize retigabine, ilaprazole, and izoga bin and other drugs. preparation[1] place 0.5 mol (approximately 103.1 g) of 1,4-p-phenylenediamine sulfate i, 1.1 mol (approximately 231 g) of analytically pure trifluoroacetic anhydride, 1.6 mol (approximately 162 g) of…