preparation method of (1s,3ar,6as)-octahydrcyclopenta[c]pyrrole-1-carboxylic acid tert-butyl ester oxalate_kain industrial additive
background and overview[1] (1s,3ar,6as)-otahydrocyclopenta[c]pyrrole-1-carboxylic acid tert-butyl ester oxalate is an s-configured nitrogen heterocycle and an intermediate of telaprevir. s-configuration nitrogen heterocycles are widely concerned as common compounds in stereochemistry and important intermediates for various drugs. (1s,3ar,6as)-otahydrocyclopenta[c]pyrrole-1-carboxylic acid tert-butyl ester oxalate can be made from cis-7-azabicyclo[3.3.0]octane hydrochloride. it is prepared through a five-step reaction. preparation[1] step…
