Preparation and application of 6

background and overview[1] 6,7-dihydro-4(5h)-benzofuranone is an important pharmaceutical intermediate. it can be prepared by the reaction of 1,3-cyclohexanedione and chloroacetaldehyde aqueous solution, and can be used to synthesize 5 -acetyl-6,7-dihydro-4(5h)-benzofuranone. preparation[1] synthesis of 6,7-dihydro-4(5h)-benzofuranone: add 1,3-cyclohexanedione (10.0g, 89.18mmol) to a 250ml round-bottomed flask, and dissolve it in 60ml of water. add 35 ml of 20%…