Preparation and application of 5-amino-2-nitrotrifluorotoluene_Kain Industrial Additive

background and overview[1-2] 5-amino-2-nitrotrifluorotoluene is an organic intermediate that can be prepared from m-chlorotrifluorotoluene in two steps. there are literature reports that it can be used to prepare pharmaceutical and optical waveguide material intermediates 4-bromo-2-nitrotrifluorotoluene and the non-steroidal anti-androgen drug flutamide. preparation[1] ①5‑chloro‑2‑nitrotrifluorotoluene in a 500ml four-neck bottle, add 111.46g (1.15mol) concentrated nitric acid and…