Preparation and application of 3-fluoro-4-nitrotoluene_Kain Industrial Additive

background and overview[1] 3-fluoro-4-nitrotoluene can be used as a pharmaceutical synthesis intermediate. it can be obtained by one-step nitration of 3-fluorotoluene. preparation[1] 3-fluoro-4-nitrotoluene is prepared as follows: the specific steps are as follows: while stirring 160cm3 of concentrated nitric acid on an ice bath, add 160cm3 of concentrated sulfuric acid dropwise below 10°c. add 90g…