Preparation and application of 3-ethynyl anisole_Kain Industrial Additive

background and overview[1] 3-ethynyl anisole is an ether derivative and can be used as a pharmaceutical synthesis intermediate. preparation[1] 3-ethynyl anisole is prepared as follows: 1) to 3-bromoanisole (5ml, 39.5mmol, 1 equivalent), triethylamine (22ml, 158mmol, 4 equivalents), cui (0.75g, 4.0mmol, 10mol%) were added to toluene (50ml) pd(pph3)2cl2 (1.4 g, 2.0 mmol, 5 mol%) in (trimethylsilyl)acetylene…