Preparation and application of 2-hydroxy-5-trifluoromethylbenzoic acid_Kain Industrial Additive

background and overview[1] 2-hydroxy-5-trifluoromethylbenzoic acid is an organic intermediate that can be prepared by the reaction of 2-methoxy-5-(trifluoromethyl)benzoic acid and iodocyclohexane. preparation[1] place 2-methoxy-5-(trifluoromethyl)benzoic acid (5.00g, 22.71mmol) in a flask containing iodocyclohexane (29.4ml, 227mmol) and dmf (25ml). the reaction mixture was refluxed for 4 h, cooled, and the solvent was removed in vacuo. the crude…