Preparation and application of 2-cyano-5-fluorobenzoic acid_Kain Industrial Additive

overview[1] 2-cyano-5-fluorobenzoic acid is an organic intermediate that can be prepared from 2-bromo-5-fluorobenzoic acid methyl ester in two steps. preparation[1] step a: heat a mixture of 2-bromo-5-fluorobenzoic acid methyl ester (5.00g, 21.5mmol) and copper cyanide (2.12g, 23.6mmol) in dmf at 90°c for 1 day. then cool to room temperature, dilute with ethyl acetate (300 ml)…