Optimizing Reaction Selectivity with 4-Dimethylaminopyridine (DMAP) in Amide Bond Formation

optimizing reaction selectivity with 4-dimethylaminopyridine (dmap) in amide bond formation introduction amide bond formation is a fundamental reaction in organic chemistry, crucial for synthesizing peptides, pharmaceuticals, polymers, and a vast array of other organic molecules. the direct coupling of carboxylic acids and amines often requires activation strategies to overcome their inherent inertness. while various coupling…