n-[5-[4-[(1,1-dioxo-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-a]pyridine -2-yl]cyclopropanecarboxamide_kain industrial additive
background and overview[1] n-[5-[4-[(1,1-dioxo-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5- a]pyridin-2-yl]cyclopropanecarboxamide can be used as a pharmaceutical synthesis intermediate. preparation[1] n-[5-[4-[(1,1-dioxo-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5- preparation of a]pyridin-2-yl]cyclopropanecarboxamide (8a): 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborane- 2-yl)-benzyl)thiomorpholine 1,1-dioxide (intermediate 1a) (20.18g, 53mmol), n-(5-bromo-[1,2,4]triazolo[1 ,5-a]pyridin-2-yl)cyclopropanecarboxamide (intermediate 7a) (16.45g, 59mmol), pd(dppf)cl2 (3.91g, 5mmol), k2co3 (22.06g, 160mmol) were added to 250ml in sequence into a three-necked flask, then add 1,4-dioxane (100 ml) and water…
