Application of 2-(2-difluoromethylphenyl)-4

background and overview 2-(2-difluoromethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborane is an organic intermediate commonly used in metal catalysis coupling reaction, application examples[1-2] report 1, cn201780052527.0 reported that 2-(2-difluoromethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborane can be used to synthesize compound 6-amino -n-(5-chloro-6-(2-(difluoromethyl)phenyl)pyridin-2-yl)pyridine-2-sulfonamide. this compound is a cf transmembrane conductance regulator (cftr) corrector. cystic fibrosis (cf) is caused by loss-of-function mutations in the cf transmembrane conductance regulator…