preparation method of (1r,3s,4s)-3-(6-bromo-1h-benzimidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester_ kain industrial additives
background and overview[1] (1r,3s,4s)-3-(6-bromo-1h-benzimidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester can harvoni is used as an intermediate in pharmaceutical synthesis, such as the preparation of a two-combination combination of the new antiviral ns5a inhibitor ledipasvir (gs5885) and the ns5b blocker sofosbuvir. it is a blockbuster hepatitis c treatment drug approved by gilead in december 2013. harvoni is the…

