4-dimethoxyphenylacetic acid_Kain Industrial Additive

background and overview[1][2] 3,4-dimethoxyphenylacetic acid, also known as homoveratrol acid, can be used to synthesize the beta-blocker drug bevantolol and the antiarrhythmic drug verapamil, etc. it is also a key intermediate in the synthesis of isoquinoline alkaloids. preparation method[1] preparation of ethyl 3,4-dimethoxyacetophenonate (3): add anhydrous aluminum trichloride (14.7 g, 0.11 mol), methylene chloride (110…