4-dichlorophenyl)piperazine dihydrochloride_Kain Industrial Additive

background and overview[1] 1-(2,4-dichlorophenyl)piperazine dihydrochloride can be used as a pharmaceutical synthesis intermediate. its free base can be prepared by buchward reaction from piperazine and 2,4-dichlorobromobenzene. preparation[1] the free base of 1-(2,4-dichlorophenyl)piperazine dihydrochloride is prepared as follows: mix and dissolve binap (219mg), palladium(ii) acetate (397mg, 0.176mmol), tbuona (1.19g, 12.3mmol), piperazine (837mg, 9.73mmol) in thf (40ml)…