3S)-3-benzamido-2-hydroxy-3-phenylpropionic acid methyl ester_Kain Industrial Additives

background and overview[1] (2r,3s)-3-benzoylamino-2-hydroxy-3-phenylpropionic acid methyl ester can be passed through 3-hydroxy-4-phenylazetidin-2-one (hpa) it is prepared in two steps and can be used to prepare paclitaxel. paclitaxel is a mitotic inhibitor or spindle poison and is a new type of anti-microtubule drug. preparation[1] step a, preparation of 3-phenylisoserine methyl ester hydrochloride dissolve 50g of 3-hydroxy-4-phenylazetidin-2-one…