3-dichloro-1-(4-nitrophenyl)-2-piperidone_Kain Industrial Additive

background and overview[1] 3,3-dichloro-1-(4-nitrophenyl)-2-piperidone is an important pharmaceutical intermediate, for example, it can be used to prepare apixaban derivatives. apixaban is a small molecule selective fxa inhibitor of pyrazole derivatives. similar to rivaroxaban, apixaban has two binding sites for factor xa. the 4-methoxyphenyl moiety in the apixaban structure binds to the s1 pocket of factor…