3-[[3-[(Dimethylamino)carbonyl]-2-hydroxyphenyl]amino]-4-[[(R)-1-(5-methylfuran-2-yl)propyl]amino Preparation method of ]-3-cyclobutene-1

background and overview[1] 3-[[3-[(dimethylamino)carbonyl]-2-hydroxyphenyl]amino]-4-[[(r)-1-(5-methylfuran-2-yl)propan [hydroxy]amino]-3-cyclobutene-1,2-dione, also known as 2-hydroxy-n,n-dimethyl-3-[[2-[[1(r)-[5-methyl -4-(1-methylethyl)-2-furyl]propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-benzamide, is a type of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds. it is a potent allosteric antagonist of cxcr1 and cxcr2 and is for scientific use only. preparation[1] 2-hydroxy-n,n-dimethyl-3-[[2-[[1(r)-(5-methyl-2-furyl)propyl]amino]-3,4-di preparation of oxy-1-cyclobuten-1-yl]amino]benzamide monohydrate (type 4): to a suspension of 10.1 g (2d1) (1.06 equivalents) in 30 ml water and…