(2s-cis)-(+)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepine-4(5h)-one preparation_kain industrial additives
background and overview[1] (2s-cis)-(+)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepine-4(5h) -ketone is a key intermediate in the synthesis of diltiazem. the current route to synthesize diltiazem is mainly to first synthesize (2s-cis)-(+)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepine zo-4(5h)-one is then obtained through a two-step reaction of n-alkylation and o-acetylation. the chemical name of diltiazem is cis-(+)-5-[(2-dimethylamino)ethyl]-2-(4-methoxyphenyl)-3-acetoxy-2,3- dihydro-1,5-benzothiazepine-4-(5h)-one hydrochloride is a selective calcium channel blocker. diltiazem is…
